Supporting Information Control of Growth Factor Binding and Release in Bisphosphonate Functionalized Hydrogels Guides Rapid Differentiation of Precursor Cells In Vitro
نویسندگان
چکیده
General. Linkers used in preparation of modified hyaluronan (HA) derivatives were synthesized according to stated literature procedures. Their structures are given in Scheme S1. Particularly, 3,3'dithiobis(propionic hydrazide) 11 and 2-(2-pyridinyldithio)ethyl hydrazinecarboxylate 32 were used to attach thioland 2-dithiopyridyl-terminated side chains to HA backbone respectively. 3-(Acrylamido-1hydroxypropane-1,1-diyl) bis(phosphonic acid) 23 was used to attach bisphosphonate ligands to the thiol groups of HA-SH derivative.
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